A recent study investigated whether it would be effective to treat fibromyalgia patients with an anti-viral and anti-inflammatory drug combination that is normally used to treat the herpes virus (cold sores or genital herpes). The anti-viral drug used in this study also treats the shingles virus (which additionally causes chickenpox). Specifically, researchers tested a famciclovir + celecoxib drug combination called IMC-1. The study was based on the hypothesis that life stressors could re-activate latent viral infections (viral infections from earlier in life that become dormant), which in turn cause fibromyalgia to develop. This hypothesis is based on anecdotal evidence of patients who develop fibromyalgia after experiencing infections and/or periods of stress. Does that sound familiar?
The results of this double-blind, placebo-controlled study were positive: participants receiving the anti-virals had significantly less pain and fatigue compared to participants who received a placebo. Encouragingly, IMC-1 was well tolerated by study participants, with few side-effects. Researchers concluded that the effectiveness of the anti-viral drugs suggests that the herpes virus may play a role in the development of fibromyalgia for some patients. Interestingly, this conclusion was based on the efficacy of the drug rather than testing the study participants for the herpes virus. I wonder whether this line of investigation could be expanded to include other potential viral triggers.
This hypothesis resonates with me because in the months before I developed fibromyalgia, I had a mumps infection, which I always attributed as a trigger for the onset of my fibromyalgia. In addition, I have had shingles, which the anti-viral used in the study also treats. This is a fascinating new area of research that will hopefully provide more answers and solutions to the treatment of fibromyalgia. In the meantime, if you have the herpes virus (or other significant viral infection) and fibromyalgia, I recommend taking this study to your doctor to see if IMC-1 might be an effective option for you!
Pridgen, W. et al. (2017). A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia. J. Pain Res., 10, 451-460. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/